兔抗SMAD2(Ab-465)多克隆抗体

Background:

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Applications:

WB

Name of antibody:

SMAD2(Ab-465)

Immunogen:

Synthesized peptide derived from C-terminal of human Smad2.

Full name:

SMAD family member 2

Synonyms：

JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2

SwissProt:

Q15796

WB Predicted band size:

52 kDa

WB Positive control:

293 cells, JurKat cells, HepG2 cells and K562 cells lysates

WB Recommended dilution:

500-3000