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英文名称: Anti-MAPK8 rabbit polyclonal antibody
别 名: JNK, JNK1, PRKM8, SAPK1, JNK-46, JNK1A2, SAPK1c, JNK21B1/2
抗 原: MAPK8
储 存: 冷冻(-20℃)
宿 主: Rabbit
相关类别: 一抗
反应种属: Human, Mouse, Rat
标 记 物: Unconjugate
克隆类型: rabbit polyclonal
技术规格
Background: |
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. |
Applications: |
ELISA, WB, IHC |
Name of antibody: |
MAPK8 |
Immunogen: |
Fusion protein of human MAPK8 |
Full name: |
mitogen-activated protein kinase 8 |
Synonyms: |
JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2 |
SwissProt: |
P45983 |
ELISA Recommended dilution: |
5000-10000 |
IHC positive control: |
Human prostate cancer and Human liver cancer |
IHC Recommend dilution: |
50-200 |
WB Predicted band size: |
48 kDa |
WB Positive control: |
Jurkat, K562, Hela, A172 cell, Mouse brain tissue lysates |
WB Recommended dilution: |
500-2000 |