兔抗SETD2多克隆抗体

Background:

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.

Applications:

ELISA, IHC

Name of antibody:

SETD2

Immunogen:

Fusion protein of human SETD2

Full name:

SET domain containing 2

Synonyms：

HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP

SwissProt:

Q9BYW2

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human tonsil and human cervical cancer

IHC Recommend dilution:

50-200