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技术规格
Background:
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).
Applications:
ELISA, IHC
Name of antibody:
SENP5
Immunogen:
Fusion protein of human SENP5
Full name:
SUMO specific peptidase 5
SwissProt:
Q96HI0
ELISA Recommended dilution:
5000-10000
IHC positive control:
Human esophagus cancer
IHC Recommend dilution:
100-200