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英文名称: Anti-TNFSF10 rabbit polyclonal antibody
别 名: tumor necrosis factor superfamily member 10 TL2; APO2L; CD253; TRAIL; Apo-2L; TNLG6A
抗 原: TNFSF10
储 存: 冷冻(-20℃)
宿 主: Rabbit
相关类别: 一抗
反应种属: Human
标 记 物: Unconjugate
克隆类型: rabbit polyclonal
技术规格
Background:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Applications:
ELISA, IHC
Name of antibody:
TNFSF10
Immunogen:
Fusion protein of human TNFSF10
Full name:
tumor necrosis factor superfamily member 10
Synonyms:
TL2; APO2L; CD253; TRAIL; Apo-2L; TNLG6A
SwissProt:
P50591
ELISA Recommended dilution:
5000-10000
IHC positive control:
Human liver cancer
IHC Recommend dilution:
25-100