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英文 名称: Anti-STX5 rabbit polyclonal antibody
别 名: syntaxin 5; SED5; STX5A
相关类别: 一抗
储 存: 冷冻(-20℃)
宿 主: Rabbit
抗 原: STX5
反应种属: Human, Mouse, Rat
标 记 物: Unconjugate
克隆类型: rabbit polyclonal
技术规格
Background:
The membrane protein syntaxin 5 (STX5) is a key component of soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE) complexes that regulate cellular protein transport, vesicle docking, and membrane fusion. Syntaxin 5 protein is found as a 42 kDa ("long") protein localized to the Golgi complex and endoplasmic reticulum, and a “short” 35 kDa isoform localized primarily to the Golgi. Formation of the syntaxin 5 SNARE complex, which also includes proteins Sec22B, Bet1, GOSR1, GOSR2, and Ykt6, allows for regulation of ER-to-Golgi transport, intra-Golgi transport, and endosome-to-Golgi retrograde transport. Research studies indicate that the syntaxin 5 SNARE complex also plays an essential role in autophagy following autophagosome formation. Intracellular protein transport mediated by the syntaxin 5 complex is required for transport and localized activity of lysosomal proteases. The experimental reduction or deletion of syntaxin 5 complex components results in non-functional lysosomes and accumulation of autophagosomes.
Applications:
ELISA, WB, IHC
Name of antibody:
STX5
Immunogen:
Fusion protein of human STX5
Full name:
syntaxin 5
Synonyms:
SED5; STX5A
SwissProt:
Q13190
ELISA Recommended dilution:
5000-10000
IHC positive control:
Human liver cancer
IHC Recommend dilution:
50-200
WB Predicted band size:
40 kDa
WB Positive control:
HepG2, A431 and Raji cell lysates
WB Recommended dilution:
500-2000