兔抗STRADB多克隆抗体

Background:

This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

STRADB

Immunogen:

Fusion protein of human STRADB

Full name:

STE20-related kinase adaptor beta

Synonyms：

PAPK; ILPIP; ILPIPA; ALS2CR2; CALS-21; PRO1038

SwissProt:

Q9C0K7

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human lymphoma and Human thyroid cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

47 kDa; 31 kDa

WB Positive control:

Mouse pancreas and spleen tissue, mouse heart tissue and 293T cells

WB Recommended dilution:

200-1000