兔抗PDCD6IP多克隆抗体

Background:

This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.

Applications:

ELISA, WB

Name of antibody:

PDCD6IP

Immunogen:

Synthetic peptide of human PDCD6IP

Full name:

programmed cell death 6 interacting protein

Synonyms:

AIP1; ALIX; HP95; DRIP4

SwissProt:

Q8WUM4

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

96 kDa

WB Positive control:

Hela cell lysate

WB Recommended dilution:

200-1000