兔抗NPC1多克隆抗体

Background:

This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol.

Applications:

ELISA, IHC

Name of antibody:

NPC1

Immunogen:

Synthetic peptide of human NPC1

Full name:

Niemann-Pick disease, type C1

Synonyms：

NPC

SwissProt:

O15118

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

25-100