兔抗RING1多克隆抗体

Background:

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.

Applications:

WB

Name of antibody:

RING1

Immunogen:

Synthetic peptide of human RING1

Full name:

ring finger protein 1

Synonyms：

RNF1; RING1A

SwissProt:

Q06587

WB Predicted band size:

42 kDa

WB Positive control:

Hela cells

WB Recommended dilution:

500-1000