兔抗PRAME多克隆抗体

Background:

This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.

Applications:

ELISA, IHC

Name of antibody:

PRAME

Immunogen:

Fusion protein of human PRAME

Full name:

preferentially expressed antigen in melanoma

Synonyms:

MAPE; OIP4; CT130; OIP-4

SwissProt:

P78395

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and human tonsil

IHC Recommend dilution:

25-100