兔抗SGOL1多克隆抗体

Background:

Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.

Applications:

WB

Name of antibody:

SGOL1

Immunogen:

Synthesized peptide derived from internal of human SGOL1.

Full name:

shugoshin-like 1

Synonyms：

SGO; Sgo1; NY-BR-85

SwissProt:

Q5FBB7

WB Predicted band size:

64 kDa

WB Positive control:

Hela cells lysate

WB Recommended dilution:

500-3000