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英文 名称: Anti-TNFSF11 rabbit polyclonal antibody
别 名: ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TNLG6B; TRANCE; hRANKL2
相关类别: 一抗
抗 原: TNFSF11
储 存: 冷冻(-20℃)
宿 主: Rabbit
反应种属: Human, Mouse, Rat
标 记 物: Unconjugate
克隆类型: rabbit polyclonal
技术规格
Background:
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
Applications:
ELISA, IHC
Name of antibody:
TNFSF11
Immunogen:
Synthetic peptide corresponding to a region derived from 304-317 amino acids of human TNFSF11
Full name:
tumor necrosis factor superfamily member 11
Synonyms:
ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TNLG6B; TRANCE; hRANKL2
SwissProt:
O14788
ELISA Recommended dilution:
5000-10000
IHC Positive control:
Human esophagus cancer;Human brain
IHC Recommended dilution:
20-100