兔抗SMAD7多克隆抗体

Background:

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

SMAD7

Immunogen:

Synthetic peptide of human SMAD7

Full name:

SMAD family member 7

Synonyms：

CRCS3, MADH7, MADH8

SwissProt:

O15105

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human liver cancer and Human thyroid cancer

IHC Recommend dilution:

50-200