兔抗SLC4A4多克隆抗体

Background:

This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. Sodium bicarbonate cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. Sodium bicarbonate cotransport is involved in bicarbonate secretion/absorption and intracellular pH regulation. Romero and Boron (1999) reviewed NBCs. Soleimani and Burnham (2000) reviewed NBCs and their regulation in physiologic and pathophysiologic states.

Applications:

ELISA, IHC

Name of antibody:

SLC4A4

Immunogen:

Fusion protein of human SLC4A4

Full name:

solute carrier family 4, sodium bicarbonate cotransporter, member 4

Synonyms：

KNBC; NBC1; NBC2; pNBC; HNBC1; hhNMC; SLC4A5; NBCe1-A

SwissProt:

Q9Y6R1

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human brain and human colon cancer

IHC Recommend dilution:

50-200