兔抗RB1多克隆抗体

Background:

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Applications:

ELISA, IHC

Name of antibody:

RB1

Immunogen:

Fusion protein of human RB1

Full name:

RB transcriptional corepressor 1

Synonyms:

RB; pRb; OSRC; pp110; p105-Rb; PPP1R130; p110-RB1

SwissProt:

P06400

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer

IHC Recommend dilution:

50-100