兔抗TP53I3多克隆抗体

Background:

The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Applications:

WB

Name of antibody:

TP53I3

Immunogen:

Synthesized peptide derived from internal of human QORX.

Full name:

tumor protein p53 inducible protein 3

Synonyms：

PIG3

SwissProt:

Q53FA7

WB Predicted band size:

36 kDa

WB Positive control:

293 cells lysate

WB Recommended dilution:

500-3000