兔抗MAP3K12多克隆抗体

Background:

This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.

Applications:

ELISA, IHC

Name of antibody:

MAP3K12

Immunogen:

Fusion protein of human MAP3K12

Full name:

mitogen-activated protein kinase kinase kinase 12

Synonyms：

DLK; MUK; ZPK; ZPKP1; MEKK12

SwissProt:

Q12852

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human colon cancer and human thyroid cancer

IHC Recommend dilution:

25-100