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英文 名称: Anti-SMURF2 rabbit polyclonal antibody
相关类别: 一抗
储 存: 冷冻(-20℃)
宿 主: Rabbit
抗 原: SMURF2
反应种属: Human, Mouse
标 记 物: Unconjugate
克隆类型: rabbit polyclonal
技术规格
Background:
E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3.
Applications:
ELISA, IHC
Name of antibody:
SMURF2
Immunogen:
Synthetic peptide of human SMURF2
Full name:
SMAD specific E3 ubiquitin protein ligase 2
SwissProt:
Q9HAU4
IHC positive control:
Human gastric cancer and human liver cancer
IHC Recommend dilution:
25-100