小鼠抗TMEM173单克隆抗体

Background:

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.

Applications:

WB, IHC

Name of antibody:

TMEM173

Immunogen:

Fusion protein of human TMEM173

Full name:

transmembrane protein 173 (TMEM173), transcript variant 1

Synonyms:

ERIS; hMITA; hSTING; MITA; MPYS; NET23; SAVI; STING

SwissProt:

Q86WV6

IHC positive control:

adenocarcinoma of human ovary tissue and carcinoma of human prostate tissue; carcinoma of human bladder tissue and carcinoma of human lung tissue

IHC Recommend dilution:

25-100

WB Predicted band size:

42 kDa

WB Positive control:

Jurkat cell lysate

WB Recommended dilution:

500-2000