兔抗MME多克隆抗体

Background:

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.

Applications:

ELISA, WB, IHC

Name of antibody:

MME

Immunogen:

Synthetic peptide of human MME

Full name:

membrane metallo-endopeptidase

Synonyms：

NEP, SFE, CD10, CALLA

SwissProt:

P08473

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human colon cancer and Human lung cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

86 kDa

WB Positive control:

293T cells

WB Recommended dilution:

500-2000