兔抗SLC8A1多克隆抗体

Background:

In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.

Applications:

ELISA, IHC

Name of antibody:

SLC8A1

Immunogen:

Synthetic peptide of human SLC8A1

Full name:

solute carrier family 8 (sodium/calcium exchanger), member 1

Synonyms:

NCX1

SwissProt:

P32418

ELISA Recommended dilution:

500-1000

IHC positive control:

Human brain and human tonsil

IHC Recommend dilution:

25-100