兔抗SDHB多克隆抗体

Background:

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

Applications:

ELISA, WB, IHC

Name of antibody:

SDHB

Immunogen:

Synthetic peptide of human SDHB

Full name:

succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

Synonyms：

IP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP

SwissProt:

P21912

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

32 kDa

WB Positive control:

293T cells and mouse brain tissue, human fetal liver tissue and hepg2 cells, Jurkat cells

WB Recommended dilution:

500-2000