兔抗HBG1/HBG2多克隆抗体

Background:

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

Applications:

ELISA, WB, IHC

Name of antibody:

HBG1/HBG2

Immunogen:

Fusion protein of human HBG1/HBG2

Full name:

hemoglobin subunit gamma 1/2

Synonyms:

fetal hemoglobin; HBGA; HBGR; HBG-T2; HSGGL1; PRO2979; TNCY; HBG-T1

SwissProt:

P69891/P69892

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer

IHC Recommend dilution:

40-200

WB Predicted band size:

16 kDa

WB Positive control:

Human plasma solution

WB Recommended dilution:

500-2000