兔抗NEK4多克隆抗体

Background:

NIMA was originally shown in Aspergillus nidulans to be necessary for entry into mitosis. NIMA-related mammalian proteins have since been identified as Nek1, Nek2, Nek3 and Nek4 (also designated STK2 or NRK2). High expression of Nek1 is seen in male and female germ cell lines of mouse. Nek2 is the closest known mammalian relative to NIMA. Like NIMA, Nek2 expression peaks at the G2 to M phase transition. Nek3 is a predominantly cytoplasmic enzyme that was detectable in all organs studied. Levels of Nek3 seem to remain unchanged throughout the cell cycle, but appear to be elevated in G0-arrested, quiescent fibroblasts. In developing testicular germ cells, differential patterns of expression were seen for Nek1, Nek2 and Nek4, indicating possible overlapping, but non-identical functions.

Applications:

ELISA, IHC

Name of antibody:

NEK4

Immunogen:

Synthetic peptide of human NEK4

Full name:

NIMA-related kinase 4

Synonyms：

NRK2; STK2; pp12301

SwissProt:

P51957

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human cervical cancer and Human lung cancer

IHC Recommend dilution:

25-100