兔抗SMG7多克隆抗体

Background:

This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Applications:

WB, IF

Name of antibody:

SMG7

Immunogen:

Synthesized peptide derived from internal of human SMG7.

Full name:

SMG7 nonsense mediated mRNA decay factor

Synonyms：

EST1C; SGA56M; C1orf16

SwissProt:

Q92540

WB Predicted band size:

127 kDa

WB Positive control:

Hela cells, Jurkat cells, 293 cells and Huvec cells lysates

WB Recommended dilution:

500-3000

IF positive control:

HepG2 cells

IF Recommend dilution:

100-500