兔抗PLCE1多克隆抗体

Background:

This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Applications:

WB

Name of antibody:

PLCE1

Immunogen:

Synthetic peptide of human PLCE1

Full name:

phospholipase C epsilon 1

Synonyms:

PLCE; PPLC; NPHS3

SwissProt:

Q9P212

WB Predicted band size:

259 kDa

WB Positive control:

HEK293 cells

WB Recommended dilution:

500-1000