兔抗PAK2(Phospho-Ser197)多克隆抗体

Background:

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.

Applications:

IHC

Name of antibody:

PAK2(Phospho-Ser197)

Immunogen:

Peptide sequence around phosphorylation site of Serine 197(T-R-S(p)-V-I) derived from Human PAK2.

Full name:

p21 protein (Cdc42/Rac)-activated kinase 2

Synonyms：

PAK65; PAKgamma

SwissProt:

Q13177

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100