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Background:
This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications:
ELISA, IHC
Name of antibody:
RPTOR
Immunogen:
Synthetic peptide of human RPTOR
Full name:
regulatory associated protein of MTOR, complex 1
Synonyms:
KOG1; Mip1
SwissProt:
Q8N122
ELISA Recommended dilution:
5000-10000
IHC positive control:
Human lung cancer and human tonsil
IHC Recommend dilution:
25-100