兔抗PLN多克隆抗体

Background:

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.

Applications:

ELISA, WB, IHC

Name of antibody:

PLN

Immunogen:

Synthetic peptide of human PLN

Full name:

phospholamban

Synonyms:

PLB; CMD1P; CMH18

SwissProt:

P26678

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human brain

IHC Recommend dilution:

25-50

WB Predicted band size:

6 kDa

WB Positive control:

Mouse heart tissue, Human heart tissue, Rat heart tissue lysates

WB Recommended dilution:

500-2000