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技术规格
Background:
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.
Applications:
ELISA, WB, IHC
Name of antibody:
SLC22A17
Immunogen:
Synthetic peptide of human SLC22A17
Full name:
solute carrier family 22, member 17
Synonyms:
BOCT, BOIT, 24p3R, NGALR, hBOIT, NGALR2, NGALR3
SwissProt:
Q8WUG5
ELISA Recommended dilution:
2000-5000
IHC positive control:
Human esophagus cancer and Human cervical cancer
IHC Recommend dilution:
25-100
WB Predicted band size:
56 kDa
WB Positive control:
Human esophagus cancer tissue
WB Recommended dilution:
500-2000