兔抗SRGAP1多克隆抗体

Background:

SRGAP1 (Slit-robo Rho GTPase activating protein 1), also known as ARHGAP13 (Rho GTPase activating protein 13), functions as a GTPase-activating protein for Cdc42 and Rho A. Expressed in kidney, testis, lung and brain, SRGAP1 contains an FCH (Fes/CIP4 homology) domain, a Rho-GAP domain and an SH3 domain. In the presence of Slit, SRGAP1 (via its SH3 domain) binds to the CC3 motif in robo (a protein responsible for mediating the repulsive effect of Slit) with higher affinity and inhibits Cdc42 activity in a robo/SRGAP-dependent manner.

Applications:

ELISA, IHC

Name of antibody:

SRGAP1

Immunogen:

Synthetic peptide of human SRGAP1

Full name:

SLIT-ROBO Rho GTPase activating protein 1

Synonyms：

ARHGAP13

SwissProt:

Q7Z6B7

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

25-100