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技术规格
Background:
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified.
Applications:
WB
Name of antibody:
ST5
Immunogen:
Synthesized peptide derived from internal of human ST5.
Full name:
suppression of tumorigenicity 5
Synonyms:
HTS1; p126; DENND2B
SwissProt:
P78524
WB Predicted band size:
126 kDa
WB Positive control:
COLO205 cells lysate
WB Recommended dilution:
500-3000