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技术规格
Background:
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
Applications:
ELISA, WB, IHC
Name of antibody:
TNK2
Immunogen:
Synthetic peptide of human TNK2
Full name:
tyrosine kinase, non-receptor, 2
Synonyms:
ACK, ACK1, ACK-1, p21cdc42Hs
SwissProt:
Q07912
ELISA Recommended dilution:
2000-10000
IHC positive control:
Human breast cancer and Human liver cancer
IHC Recommend dilution:
50-200
WB Predicted band size:
119 kDa
WB Positive control:
231 cells
WB Recommended dilution:
1000-5000