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Background:
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.
Applications:
ELISA, IHC
Name of antibody:
SIPA1
Immunogen:
Synthetic peptide of human SIPA1
Full name:
signal-induced proliferation-associated 1
Synonyms:
SPA1
SwissProt:
Q96FS4
ELISA Recommended dilution:
2000-5000
IHC positive control:
Human colon cancer and Human cervical cancer
IHC Recommend dilution:
50-200