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技术规格
Background:
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.
Applications:
ELISA, IHC
Name of antibody:
RBBP8
Immunogen:
Fusion protein of human RBBP8
Full name:
retinoblastoma binding protein 8
Synonyms:
RIM; COM1; CTIP; JWDS; SAE2; SCKL2
SwissProt:
Q99708
ELISA Recommended dilution:
2000-10000
IHC positive control:
Human thyroid cancer and human gastric cancer
IHC Recommend dilution:
100-300