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技术规格
Background:
The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit, and two smaller auxiliary beta subunits. This gene encodes the large alpha subunit, and mutations in this gene have been associated with several epilepsy, convulsion and migraine disorders. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript.
Applications:
ELISA, IHC
Name of antibody:
SCN1A
Immunogen:
Synthetic peptide of human SCN1A
Full name:
sodium channel, voltage gated, type I alpha subunit
Synonyms:
FEB3; FHM3; NAC1; SCN1; SMEI; EIEE6; FEB3A; HBSCI; GEFSP2; Nav1.1
SwissProt:
P35498
ELISA Recommended dilution:
5000-10000
IHC positive control:
Human prostate cancer
IHC Recommend dilution:
25-100