兔抗PRMT5多克隆抗体

Background:

Protein arginine methyltransferase 5 has been shown to interact with WD repeat-containing protein 77, CLNS1A, Janus kinase 2, SNRPD3 and SUPT5H.Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation.

Applications:

ELISA, WB, IHC

Name of antibody:

PRMT5

Immunogen:

Synthetic peptide of human PRMT5

Full name:

protein arginine methyltransferase 5

Synonyms：

JBP1, SKB1, IBP72, SKB1Hs, HRMT1L5

SwissProt:

O14744

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human breast cancer and Human tonsil

IHC Recommend dilution:

15-50

WB Predicted band size:

71 kDa

WB Positive control:

K562, hela and 293T cells

WB Recommended dilution:

200-1000