兔抗POLG多克隆抗体

Background:

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

POLG

Immunogen:

Synthetic peptide corresponding to a region derived from 1197-1211 amino acids of human POLG

Full name:

DNA polymerase gamma, catalytic subunit

Synonyms:

PEO; MDP1; SCAE; MIRAS; POLG1; POLGA; SANDO; MTDPS4A; MTDPS4B

SwissProt:

P54098

ELISA Recommended dilution:

5000-10000

IHC Positive control:

Human liver cancer;Human gastric cancer

IHC Recommended dilution:

10-50