兔抗PHKG2多克隆抗体

Background:

Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9C, also known as autosomal liver glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

Applications:

ELISA, IHC

Name of antibody:

PHKG2

Immunogen:

Fusion protein of human PHKG2

Full name:

phosphorylase kinase catalytic subunit gamma 2

Synonyms:

GSD9C

SwissProt:

P15735

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil and Human liver cancer

IHC Recommend dilution:

50-300