兔抗NSMCE2多克隆抗体

Background:

NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.

Applications:

ELISA, WB, IHC

Name of antibody:

NSMCE2

Immunogen:

Full length fusion protein

Full name:

NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase

Synonyms：

NSE2; MMS21; ZMIZ7; C8orf36

SwissProt:

Q96MF7

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human lung cancer and human brain

IHC Recommend dilution:

30-150

WB Predicted band size:

28 kDa

WB Positive control:

293T cell

WB Recommended dilution:

200-1000