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英文名称： UBXN1 Antigen (Recombinant Protein)
别 名： UBX domain protein 1; 2B28; SAKS1; UBXD10
储 存： 冷冻（-20℃）
相关类别： 抗原
概述
|
Fusion protein corresponding to a region derived from 1-312 amino acids of human UBXN1 |
|
Full name: |
UBX domain protein 1 |
|
Synonyms: |
2B28; SAKS1; UBXD10 |
|
Swissprot: |
Q04323 |
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Gene Accession: |
BC001372 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. |
