兔抗POLH多克隆抗体

Background:

This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

POLH

Immunogen:

Fusion protein of human POLH

Full name:

DNA polymerase eta

Synonyms:

XPV; XP-V; RAD30; RAD30A

SwissProt:

Q9Y253

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil and Human thyroid cancer

IHC Recommend dilution:

50-300

WB Predicted band size:

78 kDa

WB Positive control:

A172, 231, Jurkat, HepG2 and Hela cell lysates

WB Recommended dilution:

500-2000