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技术规格
Background:
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene.
Applications:
ELISA, WB, IHC
Name of antibody:
TAB3
Immunogen:
Fusion protein of human TAB3
Full name:
TGF-beta activated kinase 1/MAP3K7 binding protein 3
Synonyms:
NAP1; MAP3K7IP3
SwissProt:
Q8N5C8
ELISA Recommended dilution:
2000-10000
IHC positive control:
Human thyroid cancer and human brain
IHC Recommend dilution:
50-200
WB Predicted band size:
79 kDa
WB Positive control:
293T, Raw264.7, NIH/3T3, K562 and Jurkat cells
WB Recommended dilution:
1000-5000