兔抗MED23多克隆抗体

Background:

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Applications:

ELISA, IHC

Name of antibody:

MED23

Immunogen:

Synthetic peptide of human MED23

Full name:

mediator complex subunit 23

Synonyms:

SUR2; CRSP3; MRT18; SUR-2; ARC130; CRSP130; CRSP133; DRIP130

SwissProt:

Q9ULK4

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human ovarian cancer;

IHC Recommend dilution:

30-150