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Background:
NPT1, also called sodium-dependent phosphate transport protein, belongs to the organic anion transporter family, SLC17A. It is mainly expressed in the kidney transporting small organic anions such as PAH (para-aminohippurate), but it is also found in the liver and brain. NTP1 localizes to the apical membrane of renal proximal tubular cells and functions as a voltage driven organic anion/Cl-exchanger. It also plays a role in maintaining phosphate homeostasis. The expression of NPT1 is transcriptionally regulated by HNF-1 and HNF-3∫. Indomethacin and salicylate inhibit NPT1-mediated PAH transport.
Applications:
ELISA, WB
Name of antibody:
SLC17A1
Immunogen:
Synthetic peptide of human SLC17A1
Full name:
solute carrier family 17 (organic anion transporter), member 1
Synonyms:
NPT1; NPT-1; NAPI-1
SwissProt:
Q14916
ELISA Recommended dilution:
2000-5000
WB Predicted band size:
51 kDa
WB Positive control:
Human kidney pericarcinous and kidney cancer tissue
WB Recommended dilution:
500-2000