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技术规格
Background:
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease.
Applications:
WB
Name of antibody:
SNCA(Ab-125)
Immunogen:
Synthesized non-phosphopeptide derived from human Synuclein-α around the phosphorylation site of tyrosine 125 (E-A-Y(p)-E-M).
Full name:
synuclein, alpha (non A4 component of amyloid precursor)
Synonyms:
PD1; NACP; PARK1; PARK4
SwissProt:
P37840
WB Predicted band size:
14 kDa
WB Positive control:
Rat brain and mouse brain tissue lysates
WB Recommended dilution:
500-3000