手机扫码访问本站
微信咨询
中文名称： GCLC 抗原（重组蛋白）
英文名称： GCLC Antigen (Recombinant Protein)
别 名： glutamate-cysteine ligase, catalytic subunit; GCL; GCS; GLCL; GLCLC
相关类别： 抗原
储 存 ：冷冻（-20℃）
概述
|
Fusion protein corresponding to N terminal 252 amino acids of human GCLC |
技术规格
|
Full name: |
glutamate-cysteine ligase, catalytic subunit |
|
Synonyms: |
GCL; GCS; GLCL; GLCLC |
|
Swissprot: |
P48506 |
|
Gene Accession: |
BC022487 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction. |
