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Background:
This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.
Applications:
ELISA, WB
Name of antibody:
TFAP2B
Immunogen:
Synthetic peptide of human TFAP2B
Full name:
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
Synonyms:
AP-2B; AP2-B
SwissProt:
Q92481
ELISA Recommended dilution:
1000-2000
WB Predicted band size:
50 kDa
WB Positive control:
Jurkat cells
WB Recommended dilution:
200-1000